St. Louis Cardinals slugger Albert Pujols tagged his major league record 450th different pitcher for a home run, connecting off Cincinnati left-hander Ross Detwiler on Monday night in a 13-4 rout of the Reds.

Pujols hit his 694th home run overall. He had been tied with Barry Bonds for most pitchers as longball victims at 449.

Bonds leads the all-time home run list with 762, followed by Hank Aaron (755), Babe Ruth (714) and Alex Rodriguez (696).

Tyler O'Neill hit two home runs on a rainy night as the Cardinals moved a season-high 21 games over .500. He has homered in three of his last four games, including a go-ahead, three-run drive in Sunday night's 6-3 win over Atlanta.

O'Neill homered during a six-run second and again in a four-run sixth.

Miles Mikolas faced one batter over the minimum through four innings before allowing solo homers by TJ Friedl and Stuart Fairchild and a two-run drive by Chuckie Robinson while getting just one out in the fifth.

Mikolas allowed six hits and four runs in 4 1/3 innings. He is winless in six Cincinnati starts since April 14, 2018.

Chris Stratton (7-4) relieved and got the win.

Brendan Donovan extended his career-high hitting streak to 11 games with a two-run single in the Cardinals second.

Cardinals RHP Dakota Hudson (7-6, 4.23) didn't allow a hit after the third inning and retired 13 of the last 14 batters he faced while going seven innings in an 8-5 win over the Cubs at Chicago on Thursday.

Reds RHP Justin Dunn (1-2, 5.12) logged a career-high six innings in his last start, a 4-1 loss at Philadelphia on Thursday.