Jesse Winker had two hits and three RBIs, including a key two-run single in Milwaukee's five-run sixth inning, and the Brewers beat Jameson Taillon and the Chicago Cubs 9-5 on Sunday.
Christian Yelich, Garrett Mitchell and Brice Turang also had two hits apiece - part of a 13-hit attack for Milwaukee in the rubber game of the opening set between NL Central rivals. Eric Lauer (1-0) pitched 5 1/3 innings of two-run ball, settling down after a shaky start.
Patrick Wisdom hit two solo homers for Chicago, which won 4-0 on Thursday on opening day. Dansby Swanson went 1 for 4 with a walk and an RBI single.
Milwaukee went ahead to stay on Mitchell's RBI triple in the fourth, and then broke it open in the sixth.
Winker's single into the gap in left-center drove in Turang and Joey Wiemer for a 5-2 lead. Willy Adames followed with another RBI single against Julian Merryweather.
Brian Anderson added a sacrifice fly and Mitchell had another run-scoring single as the Brewers sent 10 batters to the plate.
Trailing 9-3 in the eighth, Yan Gomes nearly hit a grand slam for Chicago, but he had to settle for a sacrifice fly when Wiemer caught his drive at the wall in right field. A Cody Bellinger fielder's choice drove in another run before Wisdom was retired, ending the inning.