Fernando Tatis Jr. drove in three runs with a pair of singles, lifting the San Diego Padres to a 5-3 win over the Chicago Cubs on Wednesday night.

With runners at second and third in the seventh, Tatis hit Brandon Hughes’ 2-1 slider past diving Cubs third baseman Patrick Wisdom to score both and give the Padres a 4-3 lead. He knocked in an insurance run in the ninth with a line shot to center.

Tatis played his sixth game since returning from an 80-game drug suspension. His RBIs were his second, third and fourth since being reinstated. The 24-year-old Tatis missed all of last season, first because of a broken left wrist. When he was about to return, he was hit with his PED suspension for a positive test for the performance-enhancing substance Clostebol.

Jake Cronenworth drove in two runs with a triple as the Padres won for the third time in four games.

Chicago’s Trey Mancini lined a two-run homer and singled. Nico Hoerner had an RBI single.

Nick Martinez (2-1) pitched three scoreless innings for the win in his first relief appearance this season after four starts. Josh Hader worked around Yan Gomes' double and a walk in the ninth for his ninth save.

Chicago starter Drew Smyly yielded two runs on four hits in five innings. Hughes (0-1), the second of five Cubs relievers took the loss.

Smyly entered with 2-0 record and 0.98 ERA in his previous three outings. The lefty took a perfect game into the eighth inning in his last start, a 13-0 Cubs win over the Dodgers.

Padres RHP Seth Lugo (2-1, 2.78) starts against Cubs RHP Hayden Wesneski (1-1, 6.23) on Thursday afternoon in the series finale.