Jalen Beeks got the final two outs after entering the game with the bases loaded, Brandon Lowe and Jose Siri each hit late two-run homers and Tampa Bay beat the Chicago Cubs 4-3 on Wednesday.

Lowe connected in the seventh. Siri put Tampa Bay ahead in the eighth with his drive against Mark Leiter Jr., and the Rays pulled out a tight one after dropping 1-0 and 2-1 nail-biters.

Beeks came in with one out in the ninth after the Cubs loaded the bases against Kevin Kelly. He struck out Miles Mastrobuoni swinging at a 3-2 pitch and fell behind 3-0 to Yan Gomes.

Beeks got him to look at a strike before fouling off two pitches. He then retired Gomes on a line drive to left field and came away with his first save this year.

Seiya Suzuki chased Eflin with a leadoff double in the seventh and came around on a line-drive single to deep left by pinch hitter Trey Mancini against Colin Poche (4-1), putting Chicago on top 3-2. Mancini got thrown out trying to reach second base on the play, and the lead disappeared in a flash.

Cubs starter Justin Steele retired all nine batters before exiting with tightness in his left forearm. Manager David Ross said he pulled his pitcher for precautionary reasons and he will go for more imaging on Thursday.

Hayden Wesneski pitched one-hit ball over 3 2/3 innings and exited to cheers after walking Manuel Margot with two outs in the seventh.

Struggling RHP Jameson Taillon (0-3, 8.04) seeks his first win as the Cubs open a four-game series at San Diego on Friday. Signed in December to a four-year deal worth about $68 million, Taillon has allowed four or more runs in four straight starts for the first time in his career.