Mike Trout and Matt Thaiss delivered two-run singles during the Angels’ five-run fifth inning, and Shohei Ohtani hit his 16th homer in Los Angeles' 7-4 victory over the Chicago Cubs on Tuesday night.

Taylor Ward also homered for the Halos, who opened their six-game homestand by overcoming an early 4-0 deficit and matching their biggest comeback of the season to begin the Cubs’ first visit to Angel Stadium since 2016.

Ohtani’s fourth-inning solo homer was the Angels’ first hit, but the umpires didn’t immediately realize his blast had cleared the yellow line on the right-field fence, forcing Ohtani to sprint to third.

Mike Tauchman had a two-run single and Matt Mervis followed with a two-run double in the second inning for the Cubs, who have lost four of six. Chicago is 2-3 on its 10-game California road trip.

Tyler Anderson (3-1) overcame that rough second inning to pitch five innings of five-hit ball for the Angels, walking three and striking out five.

Chris Devenski escaped a bases-loaded, one-out jam in the seventh before striking out the side in the eighth. Carlos Estévez allowed two singles in the ninth but struck out Seiya Suzuki to finish his 15th save.

Hayden Wesneski yielded two hits and two earned runs while pitching into the fifth inning of his first start since May 13 for Chicago. The right-hander briefly went to the minors last month after struggling to a 5.03 ERA in the rotation, but he'll likely get at least one more start for the Cubs while Justin Steele recovers from his left forearm strain.

Five of the Cubs' first six batters in the second reached base, with Tauchman and Mervis providing the big hits to put Chicago up 4-0.

Ward hit his seventh homer in the seventh for Los Angeles.

Jaime Barria (2-2, 1.59 ERA) attempts to continue his strong stretch when he takes the mound for Los Angeles against Chicago's Jameson Taillon (1-3, 7.05), who will try to build on his first victory of the season last week in San Diego.