Joc Pederson and Thairo Estrada each hit two-run homers and drove in four runs as the Giants built a six-run lead through five innings in a 13-3 San Francisco Giants blowout win over the Chicago Cubs on Sunday.

Blake Sabol added two hits and two RBIs for a Giants offense that banged out 15 hits less than 24 hours after being no-hit for 7 2/3 innings by Chicago’s Kyle Hendricks in a 4-0 loss.

That helped offset a San Francisco defense that had four errors, matching the teams high this season.

Pederson finished with four hits, including a two-run drive off Cubs starter Hayden Wesneski in the first inning. He connected for a go-ahead solo shot into McCovey Cove in the third, the 101st home run into the water by a Giants player in the history of Oracle Park. It was Pederson’s 20th career multi-homer game and first since May 24, 2022, when he hit three against the New York Mets.

Estrada’s third career multi-homer game began with a solo drive off Jeremiah Estrada in the sixth. His second drive came against Javier Assad, a three-run shot in the seventh.

It’s was the first game in which the Giants had two players homer twice in a game since Aug. 16, 2019, when Kevin Pillar and Mike Yastrzemski accomplished the feat against the Diamondbacks.

Tristan Beck (1-0) pitched two innings to win for San Francisco.

Yan Gomes had two hits for the Cubs, who failed to score in the first inning after Mike Tauchman doubled on the game’s second pitch and Christopher Morel drew a one-out walk.

Wesneski (2-4) allowed four hits and five runs in three innings. He is winless since April 27.

Jameson Taillon (1-4, 7.02 ERA) faces the Pirates for the second time in his career Tuesday in Chicago. Taillon was a first-round pick by Pittsburgh in 2010, when he was selected second overall.