Kyle Higashioka caught two baserunners stealing and homered in the same inning to help Joe Musgrove and the San Diego Padres beat the St. Louis Cardinals 3-2 on Wednesday and avoid a three-game sweep.

According to Elias Sports Bureau, Higashioka became the sixth catcher since 1961 to catch multiple runners stealing and hit a home run in the same inning. The others were Sammy Taylor of the Chicago Cubs in 1961, Johnny Romano of the Chicago White Sox in 1966, Ted Simmons of the Cardinals in 1975, Joe Ferguson of the Houston Astros in 1977 and Bengie Molina of the Anaheim Angels in 2000.

Musgrove (1-1) held the Cardinals to one run and five hits in six innings, with seven strikeouts and one walk.

Robert Suarez got a five-out save, his third. Wandy Peralta hit the first two batters in the eighth with pitches and a run scored on second baseman Xander Bogaerts' throwing error on a potential double-play ball. Suarez came on and walked Contreras before getting Arenado to ground into an inning-ending double play. Suarez allowed two baserunners with one out in the ninth before striking out the final two batters.

The five-out save was significant because previous closer Josh Hader, who signed as a free agent with Houston, was reluctant to pitch multiple innings as well as to pitch three days in a row.

Thompson loaded the bases with two outs in the first and walked Jurickson Profar to bring in San Diego's first run. Fernando Tatis Jr.'s grounder in the second made it 2-0.

Thompson allowed three runs and five hits in five innings, with five strikeouts and four walks.

Lance Lynn (0-0) is scheduled to start the home opener Thursday against the Miami Marlins and LHP Ryan Weathers (0-1, 6.75).